Recent articles

004. Exploring and Quantifying the Caesium Effect I

By Thomas Dent on August 01, 2020

The kinetics of a Buchwald-Hartwig amination reaction were analysed to compare various caesium and potassium bases in early-stage process development.

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002. Estimating Reaction Completion

By Connor Taylor on July 05, 2020

A two-step telescoped synthesis of a pharmaceutical building block is to be ran. Reaction simulation in Compunetics describes when all of the initial starting material will be consumed, without the need for analytical techniques.

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001. Quantifying Catalytic Activity

By Connor Taylor on June 16, 2020

Two catalysts were identified during process development for a Suzuki-Miyaura reaction. Kinetic fitting in Compunetics was utilised to quantify their reaction rates, hence determining the optimum catalyst for this transformation.

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